Does maternal smoking influence leptin levels in term, appropriate-for-gestational-age newborns?

IMCG Pardo Department of Pediatrics, Faculty of Medical Sciences, University of Campinas – UNICAMP, São Paulo, Brazil

B Geloneze Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas – UNICAMP, São Paulo, Brazil

MA Tambascia Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas – UNICAMP, São Paulo, Brazil

AA Barros-Filho Department of Pediatrics, Faculty of Medical Sciences, University of Campinas – UNICAMP, São Paulo, Brazil

Abstract

Objectives: Leptin, a hormone produced in adipose tissue and the placenta, is correlated with neonatal growth. The aim of this study was to investigate the effect of maternal smoking during pregnancy on cord blood leptin concentrations in term, appropriate-for-gestational-age infants.

Methods: Two groups of term, appropriate-for-gestational-age newborns were selected: 19 infants of smoking mothers and 91 infants of non-smoking mothers. Neonatal anthropometric measurements were taken and leptin levels were measured by radioimmunoassay.

Results: Leptin concentrations were similar (p = 0.915) between the groups. Leptin levels correlated only with ponderal index (p < 0.01) and gestational age of the newborns (p < 0.05).

Conclusions: This study indicates that maternal smoking during pregnancy does not affect cord blood leptin levels in term, appropriate-for-gestational-age infants.

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Does maternal smoking influence leptin levels in term, appropriate-for-gestational-age newborns?

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Does maternal smoking influence leptin levels in term, appropriate-for-gestational-age newborns?

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