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Short Report

Angiogenesis-related biomarkers (sFlt-1/PlGF) in placental mesenchymal dysplasia

, , , , &
Pages 958-961 | Received 09 Feb 2016, Accepted 18 May 2016, Published online: 17 Jun 2016
 

Abstract

Determination of the soluble fms-like tyrosine kinase-1 to placental growth factor ratio (sFlt-1/PlGF) in the maternal serum is expected to aid in the monitoring and decision-making process of women at risk for placental dysfunction. We report two cases of placental mesenchymal dysplasia (PMD) with sFlt-1/PlGF correlation. The first case is a dichorionic twin pregnancy with one fetus affected by PMD and Beckwith–Wiedemann syndrome in which a high value of sFlt-1/PlGF was found, coinciding with acute maternal and fetal wellbeing decline at 31 weeks. The second case corresponds to a singleton pregnancy diagnosed of PMD with normal sFlt-1/PlGF and favorable outcome.

Declaration of interest

The authors report no conflicts of interests. The authors alone are responsible for the content and writing of this article. Spanish Ministry of Health by a grant of the “Fondo de Investigaciones Sanitarias – Instituto de Investigación Carlos III” (FIS Grant PI13/02405).

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