Does apoptotic activity have a role in the development of the placental abruption?

Abstract

Objective: The purpose of the present study is to analyses the role of apoptotic activity in placental abruption (PA) development by evaluating the level of plasma M30–M65.

Methods: The study group included 46 pregnant women who underwent caesarean sections (CS) because of PA, and the control group included 48 pregnant women who underwent CS because of obstetric causes. Venous blood samples were received from all expectants before starting the CS for the purpose of evaluating the M30–M65 levels, which are indicators of apoptotic activity in maternal plasma.

Results: The plasma M30–M65 levels were determined to be statistically significantly higher in with PA group. The sensitivity and specificity of the test were determined to be 71.7% and 64.6%, respectively in identifying the expectants with PA when the cut-off value was taken as 163.50 U/L for the plasma M30 value. The sensitivity and specificity of the test were determined to be 76.1% and 66.7%, respectively in identifying the PA when the cut-off value was taken as 295.50 U/L for the M65 value.

Conclusions: The increase of apoptotic activity induced by thrombin resulting from decidual bleeding may have a role in the development of PA.

Keywords:

• Placental abruption
• thrombin
• apoptosis
• M30
• M65

Acknowledgements

The author would like to thank Mehmet Cebel (Cebel Chemistry), Mehmet Demir (Yildiz Chemistry), Engin Ozturk, Sinan Karakecili who provided valuable support in the data collection and biochemical analysis.

Disclosure statement

The authors have stated explicitly that there are no financial support or relationships that may pose potential conflict of interest in this article.