Persistent intestinal bleeding due to severe CMV-related thrombocytopenia in a preterm newborn

Abstract

The optimal threshold for neonatal platelet transfusions in sick newborns is still uncertain. We report a congenital cytomegalovirus (CMV) infection in a premature neonate with severe thrombocytopenia who subsequently presented with necrotizing enterocolitis and intestinal bleeding. The baby recovered after platelet transfusions were discontinued and the therapy was switched from intravenous ganciclovir to oral valganciclovir. We discuss both measures, speculating on the key role of platelet transfusions.

Keywords:

• Cytomegalovirus
• intestinal bleeding
• thrombocytopenia
• congenital infection
• newborn

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

Dr Alberto Berardi has received funding (for studies related to group B streptococcal infections) from these Companies: Pfizer (2015), Putnam Associates (2016) and GSK (2017).