What can be inferred if the fetal increased nuchal translucency thickness changes?

Abstract

Objectives: To study the perinatal outcomes in the women who’s the different changes of an increased fetal nuchal translucency thickness.

Methods: Since 2013–2016, the pregnant women whose initial measurement of fetal nuchal translucency (NT) ≥ 3.5 mm would be invited to scan the NT again after a week. Between the two measurements over 1 mm, defined as “change”. According to different results between two measurements, they were divided into three groups: unchanged group, thinned group and thicken group. To follow-up and compare the perinatal outcomes among the three groups.

Results: One hundred seventy-five cases met our criteria and were retrieved in the study. There are 90 cases of the unchanged group, 60 cases of the thinned group and 25 cases of thicken group. Among three groups, the chromosomal abnormalities rate is 11.11, 21.67, and 60.0% respectively, the structure abnormalities rate is 10.0, 8.51, and 20.0%, the normal delivery rate is 76.67, 70.0, and 28.0%. There all have the significantly differences in statistics except the structure abnormalities rate.

Conclusion: The chromosomal abnormalities rate and adverse perinatal outcome rate were worse if NT continues to thicken. However, the perinatal outcome of the NT thinned group is no better than the NT unchanged case.

Keywords:

• Change
• increased nuchal translucency
• perinatal outcomes

Additional information

Funding

This study was supported by Guangdong Provincial Medical Research Foundation [A2013515], The Major Project of the Department of Science and Technology of Guangzhou [201604020012] ,The Municipal Healthcare Joint-Innovation Major Project of Guangzhou phase III. Science and Technology Planning Project of Guangdoong Province, China [2016A020218003], Science and Technology Program of Guangzhou, China [201607010341].