The impact of gestational hypothyroxinemia on the cognitive and motor development of offspring

Abstract

In the past decade, it is still controversial whether gestational hypothyroxinemia has adverse effects on fetal brain development. Animal models of maternal hypothyroxinemia have proved that thyroid hormone is necessary for the adequate development of a number of neuropsychological abilities whereas the type of deficit depends on the timing of thyroid hormone (TH) deficiency. However, different from animal experiments, evidence from clinical trials showed that the major determinant of mental and motor function delay in offspring is the gestational age at onset of maternal hypothyroxinemia. The correlation between levels of maternal FT4 in the first trimester and impaired neurodevelopment in offspring is strongest. With the progress of pregnancy, the correlation weakened gradually and disappeared until late pregnancy. Only two studies involving randomized controlled trials have examined the treatment of hypothyroxinemia with levothyroxine in pregnancy. However, both randomized trials were started too late in gestation to have a major influence on brain development.

Keywords:

• Hypothyroxinemia
• gestational
• offspring
• cognition
• motor
• free thyroxine

Disclosure statement

No potential conflict of interest was reported by the authors.