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Short Report

Maternal peripheral blood CD34+ cells for prediction of fetal kidney malformations: results from a case-control analysis

, , , , , , , , , & ORCID Icon show all
Pages 1679-1682 | Received 18 Apr 2019, Accepted 16 Jul 2019, Published online: 29 Jul 2019
 

Abstract

Purpose

To evaluate the relation between CD34+ cells count in maternal blood and potential development of fetal congenital renal abnormalities.

Materials and methods

We enrolled 16 women that gave birth to newborns carrying congenital renal malformations over a 3-year period and 48 women with uncomplicated pregnancies (controls) in a 1:3 ratio (three controls per case).

Results

CD34+ cells in the maternal peripheral blood were significantly lower in the group of women who gave birth to newborns carrying congenital renal malformations compared to the controls (p < .0001).

Conclusions

CD34+ cells in maternal blood could be validated as a potential marker to predict the development of possible kidney malformations.

Disclosure statement

No potential conflict of interest was reported by the authors.

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