Long-term outcomes of preterm infants treated with less invasive surfactant technique (LISA)

Abstract

Objective

The aim of this study is to compare the clinical outcomes at 24 months postmenstrual age of two populations receiving beractant replacement therapy using less invasive surfactant administration (LISA) versus intubation, administration of surfactant, and early extubation (INSURE). Hospital admission requirements, psychomotor development, and respiratory and neurological outcomes were studied.

Study design

This was a single-center, retrospective, and descriptive study with a sample of 60 patients (30 for each group) on nasal continuous positive airway pressure during the first 3 days of life, requiring surfactant administration.

Results

We found no significant differences between both groups on psychomotor development and respiratory and neurological outcomes.

Conclusion

Compared to INSURE technique, the administration of surfactant by LISA is feasible and safe and reduces invasive mechanical ventilation exposure with no differences in the follow-up neurodevelopmental and respiratory outcomes at 24 postmenstrual age.

Keywords:

• Beractant
• less invasive surfactant administration
• long-term outcomes
• preterm infants

Acknowledgements

The authors would like to thank Complutense University of Madrid for support in research projects. To Marisol Martínez-Tristani for helping to edit the manuscript.

Disclosure statement

MSL has acted as an expert advisor and speaker for AbbVie and has received honoraria in this regard. No potential other conflict of interest was reported by the authors.