Abstract
Introduction
Preeclampsia has the highest rate of obstetric morbidity and mortality.
Methods
We recruited 21 women with preeclampsia and 27 women with uncomplicated pregnancies. We used a quantitative protein macroarray that allowed for analysis of 40 proteins.
Results
We found a statistically significant increase in the concentration of DR3, LIF and a significant decrease of VEGF, PlGF, syndecan-4 and galectin-2, in the plasma of women with preeclampsia.
Conclusions
There are no previous studies assessing syndecan 4, galectin 2, and DR3 concentrations in women with preeclampsia; Our results indicate these proteins are new factors that play important roles in the immunological pathomechanism of preeclampsia.
Disclosure statement
The authors declare that there are no conflicts of interest regarding the publication of this paper.