Isolation of Sesquiterpenoids from Sponge Dysidea Avara and Chemical Modification of Avarol as Potential Antitumor Agents

Abstract

The marine sponge Dysidea avara contained avarol ( 1 ) and avarone ( 2 ). Avarol on acylation yielded 2',5'- O -dibenzoylavarol ( 3 ); 2',5'- O -(4-chlorobenzoyl)avarol ( 4 ); 2',5'- O -dicinnamoylavarol ( 5 ); 2',5'- O -(4-bromobenzoyl)avarol ( 6 ); 2',5'- O -dioctanoylavarol ( 7 ); 2',5'- O -(4-fluorobenzoyl)avarol ( 8 ) and diacetylavarol ( 9 ). The structural elucidation of all the compounds 1-9 have been done by spectral analysis. The cytotoxicity of these compounds were also determined and evaluated. Compounds 6 and 9 showed selective cytotoxicity against Hepa (human hepatoma) and KB cell lines respectively.

Keywords:

• Dysidea Avara
• Avarol
• Avarone
• Avarol Analogs
• Cytotoxicities