Synthesis and Biological Screening of 7-Hydroxy-4-Methyl-2 H -Chromen-2-One, 7-Hydroxy-4,5-Dimethyl-2 H -Chromen-2-One and their Some Derivatives

Khalid Mohammed Khan HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi, 75270, Pakistan

Zafar S. Saify Faculty of Pharmacy, University of Karachi, Karachi, 75270, Pakistan

Saeedan Begum Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan

Fatima Noor Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan

Muhammad Zarrar Khan Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan

Safdar Hayat HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi, 75270, Pakistan

M. Iqbal Choudhary HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi, 75270, Pakistan

Shahnaz Perveen PCSIR Laboratories Complex, Off University Road, Karachi, 75280, Pakistan

Atta-Ur-Rahman HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi, 75270, Pakistan

Zia-Ullah HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi, 75270, Pakistan

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Abstract

7-Hydroxy-4-methyl-2 H -chromen-2-one (2) , 7-hydroxy-4,5-dimethyl-2 H -chromen-2-one (15) and their some derivatives were synthesized for exploring selected biological screening. The compounds 9 and 13 had shown high degree of cytotoxic activity. Three compound 9 , 10 and 13 showed high degree of bactericidal activity amongst the present series.

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Synthesis and Biological Screening of 7-Hydroxy-4-Methyl-2 H -Chromen-2-One, 7-Hydroxy-4,5-Dimethyl-2 H -Chromen-2-One and their Some Derivatives

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Synthesis and Biological Screening of 7-Hydroxy-4-Methyl-2 H -Chromen-2-One, 7-Hydroxy-4,5-Dimethyl-2 H -Chromen-2-One and their Some Derivatives

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