Mucigerin, a new coumarin from Calophyllum mucigerum (Guttiferae)

Abstract

Our recent studies on the stem bark of Calophyllum mucigerum (Guttiferae) have yielded a new coumarin mucigerin, a prenylated xanthone cudraxanthone C and the common steroidal triterpenes friedelin and stigmasterol. Structural elucidations of these compounds were achieved using ¹H NMR, ¹³C NMR, DEPT, COSY, HETCOR and HMBC experiments while MS gave the molecular masses. Cytotoxic assays using CEM-SS cell line (T-lymphoblastic leukemia) on the crude extracts of the stem bark indicated some activity. The crude extracts were also found to be moderately toxic against the larvae of Aedes aegypti. This article reports the isolation and identification of mucigerin as well as bioassay data.

Keywords:

• Calophyllum mucigerum
• Coumarin
• Cytotoxic
• Larvicidal
• Aedes aegypti
• Toxicity
• Mucigerin

Acknowledgements

The authors wish to thank Dr Jegak Uli for collection of plant samples, Mr. Tan Boon Keat for conducting cytotoxic testings and the Malaysian IRPA grant for financial support.