Phoebegrandine C, A novel proaporphine-tryptamine dimer, from Phoebe grandis (Nees) merr.

Abstract

A novel proaporphine-tryptamine dimer alkaloid, named phoebegrandine C1, was isolated from the leaves ofPhoebe grandis(Nees) Merr. Its structural elucidation was carried out using spectroscopic techniques, notably 2D NMR.

Keywords:

• Proaporphine-tryptamine dimer
• Phoebegrandine C
• NMR
• Phoebe grandis
• Alkaloid

Acknowledgements

The authors are grateful to the Malaysian Government (IRPA vote: 09-02-03-0253) and the French Embassy in Malaysia for their financial support. We also thank Mr. Marc Litaudon and Mr. Christian Girard of ICSN for the HRMS data.