Antioxidant Iridoid Glucosides From Wendlandia Formosana

B. Lakshmana Raju Department of Medical Chemistry, School of Pharmacy, Taipei Medical University, No.250, Wu-Hsing Street, Taipei 110-31, Taiwan, ROC

Shwu-Jiuan Lin Department of Medical Chemistry, School of Pharmacy, Taipei Medical University, No.250, Wu-Hsing Street, Taipei 110-31, Taiwan, ROC

Wen-Chi Hou Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110-31, Taiwan, ROC

Zhi-Yang Lai Department of Internal Medicine, Division of Cardiology, Taipei Medical University, Taipei 110-31, Taiwan, ROC

Pan-Chun Liu Department of Medical Chemistry, School of Pharmacy, Taipei Medical University, No.250, Wu-Hsing Street, Taipei 110-31, Taiwan, ROC

Feng-Lin Hsu Department of Medical Chemistry, School of Pharmacy, Taipei Medical University, No.250, Wu-Hsing Street, Taipei 110-31, Taiwan, ROC; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110-31, Taiwan, ROC

Abstract

Two new iridoid glucosides of 10-O-caffeoyl scandoside methyl ester (3), and 6-methoxy scandoside methyl ester (4) besides the known compounds of scandoside methyl ester (1), methyl deacetyl asperulosidate (2), 10-O-caffeoyl daphylloside (5), phytol (6), and ursolic acid (7) were isolated from the leaves of Wendlandia formosana. Structure elucidation of the new iridoid glucosides was based on interpretation of high-resolution 1D and 2D NMR spectral data and chemical conversions. Antioxidant activity of Compounds (1–5) against diphenylpicrylhydrazyl (DPPH) and hydroxyl radical, and peroxynitrite was reported.

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Acknowledgements

This work was supported by a grant from the National Science Council of the Republic of China (NSC 89-2323-B-038-001). We thank Ms. Shwu-Hui Wang, Center for Instrumentation, Taipei Medical University, for recording the NMR data and Ms. Shu-Yun Sun (Taipei Regional Analytical Instrumentation Center, NSC) for measurement of the low- and high-resolution FABMS.

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Antioxidant Iridoid Glucosides From Wendlandia Formosana

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Antioxidant Iridoid Glucosides From Wendlandia Formosana

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