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Abstract
The fatty acids 17,18-dihydroxyoctadeca-9,11,13,15-tetraynoic acid (mkiluaynoic acid A) and 18-hydroxyoctadeca-9,11,13,15-tetraynoic acid (mkiluaynoic acid B), 5,7,3′,4′-tetrahydroxyflavanol, 3,4-dihydroxybenzoic acid and a mixture of stearic and oleic acids were isolated from fruits and stem barks of Mkilua fragrans (Annonaceae). Mkiluaynoic acid A exhibited antifungal activity against Candida albicans comparable with that of the standard antifungal agent Ketoconazole. Structural determination was achieved by analysis of spectroscopic data. The flower stalks yielded essential oils that mainly consisted of sesquiterpenoids as revealed by GC–MS analysis, whereby 14 sesquiterpenes and four other compounds were identified.
Acknowledgement
Financial support through a Sida/SAREC grant to the Faculty of Science, University of Dar es Salaam is gratefully acknowledged. We thank Mr. L.B. Mwasumbi of the Herbarium, Department of Botany at the University of Dar es Salaam for locating and identifying the investigated plant species. DLB thanks the German Academic Exchange Services (DAAD) and NAPRECA for an M.Sc. fellowship under the DAAD/NAPRECA Fellowship Scheme.