![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
Four new epoxy taxoids were isolated from the needles of Taxus cuspidata. Their structures were established as 2α,9α-diacetoxy-5α-cinnamoyloxy-11,12-epoxy-10β-hydroxytax-4(20)-en-13-one (1), 2α,10β-diacetoxy-5α-cinnamoyloxy-11,12-epoxy-9α-hydroxytax-4(20)-en-13-one (2), 2α,9α-diacetoxy-11,12-epoxy-10β,20-dihydroxytax-4-en-13-one (3) and 2α,10β-diacetoxy-11,12-epoxy-9α,20-dihydroxytax-4-en-13-one (4) on the basis of spectral analysis including 1H-NMR, 13C-NMR, 1H–1H-COSY, HSQC, HMBC and HRFABMS. Compounds 3 and 4 are the first example of 11,12-epoxy taxoids with C-4 double bond found in T. cuspidata.
Acknowledgements
The project was sponsored by the Foundation for Researching New Drugs of People's Republic of China (No: 2003AA2Z3527) and by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of the People's Republic of China. We thank Dr. Takayuki Oritani, Emeritus Professor of Tohoku University for his support.