Phytochemical studies and antibacterial activity of Centaurium pulchellum Druce

Abstract

Two isocoumarin derivatives, one new, erythricin (1) and a known erythrocentaurin (2) were isolated from the whole plant of Centaurium pulchellum Druce. The ¹³C-NMR data of compound 2 are described. The structures of compounds 1, 2 were elucidated on the basis of spectral analysis including 2D-NMR experiments. Antibacterial and brine shrimp lethality assays are also described on the fractions of the plant extract.

Keywords:

• Centaurium pulchellum Druce
• Antibacterial activity
• Isocoumarin derivatives
• Erythricin
• Erythrocentaurin

Acknowledgement

We are grateful to Professor Dr M. Iqbal Choudhry, Acting Director, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, for spectral analysis.