Acerolide, a new cytotoxic cembranolide from the soft coral Pseudopterogorgia acerosa

Abstract

A new cembranolide, acerolide (1) together with the known compound pseudopterolide (2) were isolated from the 2-propanol extract of the soft coral Pseudopterogorgia acerosa. The structure of 1 was determined on the basis of detailed spectroscopic analysis. Compound 1 showed moderate in vitro cytotoxicity against a panel of 14 tumor cell lines.

Keywords:

• Pseudopterogorgia acerosa
• Cembranolide
• Cytotoxic activity

Acknowledgements

We wish to thank the assistance of P. Lopez in the taxonomic identification of the specimen and L. García-Grávalos for performing the cytotoxicity assays. The technical assistance of E. Millán in recording the optical rotations, IR, UV and mass spectra is also fully acknowledged.

Notes

§Present address: Analytical Technologies Department, Lilly S.A., Avda. de la Industria 30, 28108 (Alcobendas) Madrid, Spain.

Additional information

Notes on contributors

David Montalvo§

§Present address: Analytical Technologies Department, Lilly S.A., Avda. de la Industria 30, 28108 (Alcobendas) Madrid, Spain.