An expeditious and environmentally friendly synthesis of 3-substituted isocoumarins using microwave irradiation

Khalid Mohammed Khan H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, PakistanCorrespondence[email protected]

Sumbul Ahmed H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan

Zulfiqar Ali Khan H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan

Mubeen Rani H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan

Shahnaz Perveen PCSIR Laboratories Complex Karachi, Off University Road, Karachi, Pakistan

Wolfgang Voelter Interfakultäres Institut für Biochemie der Universität Tübingen, Tübingen, Germany

Abstract

A microwave-assisted, environmentally friendly, high-yielding, time-saving synthesis of medicinally important 3-substituted isocoumarins was carried out in a single step by direct condensation of homophthalic acid with aryol and acyl chlorides under solvent-free conditions without any solid support. The synthesised isocoumarins were structurally characterised by microanalysis, ¹H NMR, EI, IR and UV.

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Acknowledgement

The authors are thankful to the Higher Education Commission (HEC) Pakistan for generous financial support under the ‘National Research Program for Universities’.

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An expeditious and environmentally friendly synthesis of 3-substituted isocoumarins using microwave irradiation

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An expeditious and environmentally friendly synthesis of 3-substituted isocoumarins using microwave irradiation

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