Antioxidants and a new dihydroisocoumarins from Polygala hongkongensis Hemsl

Jian-Feng Wu Shenyang Pharmaceutical University, Shenyang 110016, China; School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China; State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Shenzhen 518057, China; Foshan University, Foshan 528000, China

Si-Bao Chen State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Shenzhen 518057, China; Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100094, China

Jing-Chun Gao Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100094, China

Hao-Liang Song State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Shenzhen 518057, China

Li-Jun Wu Shenyang Pharmaceutical University, Shenyang 110016, China

Shi-lin Chen State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Shenzhen 518057, China; Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100094, China

Peng-Fei Tu Shenyang Pharmaceutical University, Shenyang 110016, China; School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, ChinaCorrespondence[email protected]

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Abstract

A new dihydroisocoumarins, 6-methoxy-8-hydroxy-3-(4-hydroxyphenyl)isochroman-1-one, named as hongkongenin (1), and seven known flavonoids were isolated from the methanol extract whole plant of Polygala hongkongensis Hemsl. Their structures were established on the basis of UV, IR, NMR, and MS spectral data. It is the first report of the occurrence of isocoumarins in Polygala, and the known compounds 2–8 were isolated from this plant for the first time. Flavonoids showed potent antioxidant activities in vitro against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, hydroxyl radicals, and reductive activity to Fe³⁺.

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Antioxidants and a new dihydroisocoumarins from Polygala hongkongensis Hemsl

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Antioxidants and a new dihydroisocoumarins from Polygala hongkongensis Hemsl

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