A new fatty acid ester of triterpenoid from Celastrus rosthornianus with anti-tumor activitives

Abstract

The methanol extract of the stalks of Celastrus rosthornianus Loes. afforded a new fatty acid ester of triterpene: 1β,3β-dihydroxy-olean-9(11),12-dienyl-3-palmitate (1), and three known compounds β-amyrin palmitate (2), 3β-hydroxy-11-oxo-olean-12-enyl-3-palmitate (3) and lupeol palmitate (4). Their structures were established by HRMS, 1D and 2D NMR experiments, as well as, by chemical degradation. The new compound showed cytotoxicity against human cervical squamous carcinoma (Hela) cells.

Keywords:

• Celastrus rosthornianus
• Fatty acid esters
• GC-MS
• HRMS
• NMR