Antimicrobial effect and resistant regulation of Glycyrrhiza uralensis on methicillin-resistant Staphylococcus aureus

Ji-Won Lee Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, Korea

Young-Ju Ji Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, Korea

Mi-Hee Yu Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, Korea

Mi-Hyang Hwang Bo Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, Korea

Hwa-Jeong Seo Department of Food Science and Technology, Keimyung University, Daegu, Korea; Daegu Technopark Bio Industry Center, Daechoen-dong, Dalseo-gu, Daegu, Korea

Sam-Pin Lee Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, Korea

In-Seon Lee Department of Food Science and Technology, Keimyung University, Daegu, Korea; The Center for Traditional Microorganism Resources Center, Keimyung Universit, KoreaCorrespondence[email protected]

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Abstract

In the present study, we investigated antimicrobial activity of Glycyrrhiza uralensis against various strains of methicillin-resistant Staphylococcus aureus (MRSA) (KCCM 11812, 40510, 40512). Glycyrrhiza uralensis was extracted by 80% MeOH and fractionated by organic solutions. The extract and fractions showed antimicrobial activity against standard S. aureus as well as MRSA. In the minimum inhibitory concentration test, G. uralensis showed 0.25 mg mL⁻¹ in hexane fraction and 0.10–0.12 mg mL⁻¹ in chloroform fraction. Especially, chloroform fraction showed 2.5 times higher antimicrobial activity than penicillin. Furthermore, chloroform fraction correlated with MRSA gene expression (MecA, MecI, MecRI, FemA). These results suggest that G. uralensis may have potent antimicrobial activity and thus, this medicinal herb can be a suitable phytotherapeutic agent for treating MRSA infections.

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Acknowledgements

This work was supported by the Ministry of Commerce, Industry and Energy (MOCIE) through the Center for Traditional Microorganism Resources (TMR) at Keimyung University, Republic of Korea.

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Antimicrobial effect and resistant regulation of Glycyrrhiza uralensis on methicillin-resistant Staphylococcus aureus

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Antimicrobial effect and resistant regulation of Glycyrrhiza uralensis on methicillin-resistant Staphylococcus aureus

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