Isolation of a new glycoside from starfish, Asterias amurensis Lutken, and its stimulation activity on the proliferation of the UMR106 cell

Abstract

A new glycoside compound (1) was isolated from the starfish Asteria amurensis Lutken. The structure for compound 1 was identified as 1-O-{β-D-quinovopyranosyl–(1-2)-β-D-fucopyranosyl-(1-4)-[β-D-fucopyranosyl(1-2)] β-D-quinovopyranosyl}-butanol by extensive NMR experiments as well as chemical evidence. The effects of compound 1 on UMR106 cell proliferation were screened by MTT assay. The results indicate that compound 1 (0.01–100 µM) significantly promotes osteoblastic proliferation.

Keywords:

• starfish
• Asterias amurensis
• glycosides
• UMR106 cell proliferation

Acknowledgements

This work was supported by grants from the China Postdoctoral Science Foundation (2005037065) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, China.