New cytotoxic oxygenated sterols from marine bryozoan Bugula neritina

Abstract

Two new oxygenated sterols, 3β,24(S)-dihydroxycholesta-5,25-dien-7-one (1) and 3β,25-dihydroxycholesta-5,23-dien-7-one (2), were isolated from the marine bryozoan Bugula neritina. Their chemical structures were established on the basis of spectroscopic analysis. Both compounds exhibited cytotoxicity to three human cancer cell lines (HepG2, HT-29 and NCI-H460), with IC₅₀ values between 22.58 and 53.41 µg mL⁻¹.

Keywords:

• marine bryozoan
• Bugula neritina
• steroid
• cytotoxicity

Acknowledgements

This work was financially supported by the National High Technology Research and Development Program of China (863 Project, No. 2007AA09Z401).