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Abstract
Antioxidant activity of several classes of lichen metabolites were assessed in the in vitro superoxide radical (SOR), nitric oxide radical and 2,2-diphenyl-1-picrylhydrazil radical scavenging assays. The despsides sekikaic acid and lecanoric acid showed promising antioxidant activity in SOR assay with IC50 values of 82.0 ± 0.3 µmol and 91.5 ± 2.1 µmol, respectively, while the depsidone lobaric acid exhibited an IC50 value of 97.9 ± 1.6 µmol, all relative to the standard, propyl gallate (IC50 = 106.0 ± 1.7 µmol). One of the most abundant mononuclear phenolic compounds, methyl-β-orcinol carboxylate was found to be a potent NO scavenger (IC50 = 84.7 ± 0.1 µmol), compared to the standard rutin (IC50 = 86.8 ± 1.9 µmol).
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Acknowledgements
Authors thank the National Research Council, National Science Foundation, Sri Lanka, for research funding and the award of a full scholarship by the National Science Foundation and a travel grant to visit HEJ Pakistan by the University Grants Commission to Vinitha M. Thadhani.