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Abstract
The antiviral activities of extracts from Daucus maritimus seeds were investigated against the reverse transcriptase of human immunodeficiency virus (HIV) type 1 and a panel of RNA-dependent RNA polymerases of dengue virus, West Nile virus (WNV) and hepatitis C virus (HCV). The extracts showed moderate to potent inhibition rates against the four viral polymerases. The ethyl acetate extract exhibited a potent inhibitory effect against WNV's RdRp, with an IC50 value of 8 µg mL−1. The F 2 fraction exhibited potent inhibitory activity against WNV and HCV's RdRps, with IC50 values 1 and 5 µg mL−1, respectively. The P 2 fraction also showed potent inhibitory effects on WNV and HCV's RdRps, with IC50 values 2.7 and 4 µg mL−1, respectively. The results suggest that these extracts are candidates for the development of new anti-WNV RpDp and anti-HCV RpDp agents.
Acknowledgements
The authors thank Professor M. Chaib (Department of Biology, Faculty of Science, University of Sfax, Tunisia) for the identification of plant.