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Abstract
The anti-inflammatory activity and the mechanism of action of Gentiana striata Maxim. has been investigated. The most active phase, the ethyl acetate extract of Gentiana striata Maxim. (EGS), displayed potent inhibitory activity on feet oedema of rheumatoid arthritis (RA) inflicted rats. This anti-inflammatory activity might be partly based on the notable reduction of prostaglandin E2 (PGE2) and nitric oxide (NO) levels. Six further compounds isolated from EGS have previously been reported as having anti-inflammatory activity.
Acknowledgements
The authors thank Dr Allen Gamble (Australian National University, Australia), whose comments and corrections of manuscript significantly improved the content of this article. Support of this research was partially provided by National University Innovation Experiment Program.