Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis

Joaquim S. Costa Júnior Departamento de Química, Instituto Federal do Piauí, PI 64000-040, Teresina, Brasil

Antonia Amanda Cardoso de Almeida Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, PI 64049-550, Teresina, Brasil

Alexandre de Barros Falcão Ferraz Laboratório de Genética Toxicológica, Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil, RS 92425-900, Canoas, Brasil

Raíssa Rebés Rossatto Laboratório de Genética Toxicológica, Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil, RS 92425-900, Canoas, Brasil

Teresinha G. Silva Departamento de Antibióticos, Universidade Federal de Pernambuco, PE 50670-901, Recife, Brasil

Paulo B.N. Silva Departamento de Antibióticos, Universidade Federal de Pernambuco, PE 50670-901, Recife, Brasil

Gardenia C.G. Militão Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, PE 50670-90, Recife, Brasil

Antonia Maria das Graças Lopes Citó Departamento de Quimica, Universidade Federal do Piauí, PI 64049-550, Teresina, Brasil

Lorena Citó Lopes Resende Santana Departamento de Bioquimica e Farmacologia, Universidade Federal do Piauí, PI 64049-550, Teresina, Brasil

Fernando Aécio de Amorim Carvalho Departamento de Bioquimica e Farmacologia, Universidade Federal do Piauí, PI 64049-550, Teresina, Brasil

Rivelilson M. Freitas Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, PI 64049-550, Teresina, Brasil; Departamento de Bioquimica e Farmacologia, Universidade Federal do Piauí, PI 64049-550, Teresina, BrasilCorrespondence[email protected]

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Abstract

Garcinielliptone FC (GFC), a natural prenylated benzophenone, was extracted from Platonia insignis Mart. (Clusiaceae), a native plant commonly known as bacuri and used in traditional Brazilian medicine for the treatment of skin diseases. The aim of this study was to evaluate the cytotoxic and leishmanicidal effects of GFC using in vitro models. The experimental data demonstrated that the polyisoprenylated benzophenone GFC possesses cytotoxic and leishmanicidal activities.

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Acknowledgements

This study was supported by CNPq, IFPI, and FAPEPI through grants and fellowships.

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Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis

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Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis

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