Hyperinakin, a new anti-inflammatory phloroglucinol derivative from Hypericum nakamurai

Yuan-Bin Cheng School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, Taiwan

Ahmed Eid Fazary School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, Taiwan

Yu-Chi Lin School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, Taiwan

I-Wen Lo School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, Taiwan

Seow-Chin Ong School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, Taiwan

Shun-Ying Chen Division of Silviculture, Taiwan Forestry Research Institute, Taipei 100, Taiwan

Ching-Te Chien Division of Silviculture, Taiwan Forestry Research Institute, Taipei 100, Taiwan

Yen-Jung Lin Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 100, Taiwan

Wan-Wan Lin Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 100, Taiwan; Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan

Ya-Ching Shen School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, TaiwanCorrespondence[email protected]

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Abstract

Phytochemical investigation of Hypericum nakamurai (Masamune) Robson has led to the isolation of three phloroglucinol derivatives 1–3. The structures of these compounds were determined by the analysis of their spectroscopic data (IR, mass and UV), and by the application of 1-D and 2-D-NMR techniques. Hyperinakin (1) is a new compound. The anti-inflammatory activities of compounds 1–3 were also tested and evaluated. A biogenetic pathway for compounds 1–3 was also proposed.

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Acknowledgement

The authors thank the National Science Council, Republic of China (NSC-95-2320-B-002-118-MY3) for providing financial support.

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Hyperinakin, a new anti-inflammatory phloroglucinol derivative from Hypericum nakamurai

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Hyperinakin, a new anti-inflammatory phloroglucinol derivative from Hypericum nakamurai

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