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Abstract
Two new cassane-type diterpenes, Caesalpinolide F (1) and Caesalpinolide G (2) were isolated from Caesalpinia minax Hance. Their structures were elucidated on the basis of 1D and 2D NMR, MS and CD analysis. Compounds 1 and 2 were tested against colon carcinoma (HCT-8) and breast cancer (MCF-7) human cancer cell lines, and showed mild cytotoxicity activities.
Acknowledgements
The work was supported by the technological large platform for comprehensive research and development of new drugs in the Eleventh Five-Year ‘Significant New Drugs Created’ Science and Technology Major Projects (No. 2009ZX09301-003). National Natural Science Foundation of China (No. 30 973 626), the Science and Technology Grant of Guangxi Province (No. 0 639 039) and special purpose of basic scientific research operation grant for Commonweal Academy and Institute of Central Authorities (No. YZ-1-24). Innovation capacity-building in Guangxi Science and Technology Agency (0443002-2).