A new cyclonerol derivative from a marine-derived fungus Ascotricha sp. ZJ-M-5

Lei-Rui Xie Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materiel Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Dan-Yi Li School of Traditional Chinese Materiel Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Zhan-Lin Li Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materiel Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Hui-Ming Hua Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materiel Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Pei-Le Wang Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materiel Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Xin Wu School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, ChinaCorrespondence[email protected]

Abstract

A new sesquiterpene, ascotrichic acid (1), was isolated from a marine-derived fungus Ascotricha sp., together with the other two known analogues, cyclonerodiol (2) and 10(Z)-cyclonerotriol (3). Its structure was established by spectroscopic methods (1D and 2D NMR, HR-ESI-MS).

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant No. 20872094).

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A new cyclonerol derivative from a marine-derived fungus Ascotricha sp. ZJ-M-5

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A new cyclonerol derivative from a marine-derived fungus Ascotricha sp. ZJ-M-5

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