Five new secondary metabolites from Monascus purpureus-fermented Hordeum vulgare and Sorghum bicolor

Abstract

Long grains of Hordeum vulgare and Sorghum bicolor were individually fermented with Monascus purpureus MTCC 369 under solid state fermentation. The aqueous extract of Monascus which fermented H. vulgare and S. bicolor was found to contain five different new metabolites. Silica gel column chromatography of the aqueous extract with a linear gradient of ethyl acetate, acetonitrile and carbon tetrachloride (v/v) yielded five new metabolites named benzopranyl capriate (9H-1-isoprenyl-benzopyran-5-isopropanoic acid-6-ol-6-n-decanoate), shorghumoic acid (n-octadec-8,11-dien-7α-ol-1-oic acid) and sorghumflavin A (2-n-butyloxo-6-β-hydroxy-7-β-isoprenyl ankaflavin) from Monascus-fermented S. bicolor, while hordeumflavin B (2-n-undecanyloxo-7-β-isoprenyl ankaflavin) and vulgaredilone (2-dodecanyl-7-β isopranyl monoscodilone) from Monascus-fermented H. vulgare.

Keywords::

• Monascus purpureus
• Hordeum vulgare
• Sorghum bicolor
• hordeumflavin B
• sorghumflavin A
• shorghumoic acid
• vulgaredilone

Acknowledgements

All the authors acknowledge the Department of Biotechnology, Government of India, for sponsoring the research project under Rapid Grant of Young Investigator Scheme.