A new polyketide from Diaporthe sp. SXZ-19, an endophytic fungal strain of Camptotheca acuminate

Abstract

A new polyketide named (1R,2E,4S,5R)-1-[(2R)-5-oxotetrahydrofuran-2-yl]-4,5-dihydroxy-hex-2-en-1-yl(2E)-2-methylbut-2-enoate (1), along with eight known polyketide including one monoterpene (2), three linear furanopolyketides (3–5) and four lovastatin analogues (6–9), was isolated from the endophytic fungal strain Diaporthe sp. SXZ-19 of Camptotheca acuminate. The chemical structures of compounds 1–9 were elucidated on the basis of extensive spectroscopic analyses, including FT-ICR-MS, IR and 1D and 2D NMR experiments. The in vitro cytotoxicity of 1 against the human colon cancer cell line HCT 116 was evaluated but showed no evident activity.

Keywords::

• Diaporthe sp
• Camptotheca acuminate
• endophytic fungi
• polyketide
• cytotoxicity

Acknowledgements

The authors gratefully acknowledge the financial support from the 973 Program (2010CB833802; 2012CB721000), National Science Fund for Distinguished Young Scholars to Y.-M. Shen (No. 30325044) and the Key Grant Project of Chinese Ministry of Education (No. 306010).