Two new cytotoxic iridoid esters from the rhizomes and roots of Patrinia heterophylla Bunge

Abstract

Two new iridoid esters, named patriheterdoid B, C, have been isolated from the rhizomes and roots of Patrinia heterophylla Bunge. Their structures were elucidated by extensive spectroscopic technologies. Together with patriheterdoid B, C, two known analogues have been isolated and identified by means of mass spectrometry and ¹H and ¹³C NMR spectrometry. These compounds showed cytotoxic activity against SGC-7901, PC3 cell lines.

Keywords::

• Patrinia heterophylla Bunge
• iridoid ester
• patriheterdoid B, C
• cytotoxic activity

Acknowledgements

This study was supported by Zhejiang Provincial Medicines and Health Science and Technology Program (2012KYB137), 2012 Zhejiang Provincial major science and technology project (2012C13017-1) and the Program for Zhejiang Leading Team of Science and Technology Innovation (2010R50044-12).