New briarane-type diterpenoids from gorgonian Ellisella dollfusi from the South China Sea

Abstract

Two new briarane-type diterpenoids, dollfusilin A (1) and dollfusilin B (2), along with five known briarane-type diterpenoids (3–7), were isolated from the gorgonian Ellisella dollfusi collected from the South China Sea. The structures of the two new compounds (1 and 2) were elucidated through a comprehensive analysis of spectroscopic data, especially 2D NMR. The bioactivities of the isolated compounds were evaluated using the zebrafish toxicity model.

Keywords::

• gorgonian
• Ellisella dollfusi
• briarane
• diterpenoid
• structure elucidation
• bioactivity

Acknowledgements

This work was supported by the Key Program of the National Natural Science Foundation of China (No. 41130858), the National Natural Science Foundation of China (Nos 41176121 and 81172977), the National High Technology Research and Development Program of China (863 Program) (No. 2013AA093001) and the Natural Science Foundation of Shandong Province (Nos ZR2011DQ019 and ZR2011HM085).