A new sesquiterpenoid from Scaphium macropodum (Miq.) Beumee

Abstract

A new sesquiterpenoid, malayscaphiol (1), and three known compounds, lupeol (2), lupenone (3) and stigmasterol (4), were isolated from the methanolic extract of the stem bark of Scaphium macropodum. The structures of the isolated compounds were determined using several spectroscopic methods, including UV–vis, FT-IR, 1D and 2D NMR, and mass spectrometer. Major isolated compounds were assayed for cytotoxicity and anti-acetylcholinesterase activities. The chemotaxonomy significance of this plant was also discussed.

Keywords::

• Sterculiaceae
• Scaphium macropodum
• sesquiterpenoid
• malayscaphiol
• cytotoxicity
• anti-acetylcholinesterase

Acknowledgement

The authors would like to thank the Faculty of Applied Sciences, Universiti Teknologi MARA for financing this research project.