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Abstract
In our continuing effort to discover more new cytotoxic sesquiterpenoids from Solanum lyratum, one new eudesmane-type sesquiterpenoid (1, 3-keto-eudesm-9β,11-diol, named lyratol G), together with one known eudesmane-type sesquiterpenoid (2, 1β-hydroxy-1,2-dihydro-α-santonin), was obtained. The structure of the new sesquiterpenoid was elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D NMR (1H–1H COSY, HMQC, HMBC and ROESY). In vitro, two sesquiterpenoids were found to exhibit significant cytotoxicity against three cancer cell lines (P-388, HONE-1 and HT-29), and gave IC50 values in the range of 3.1–6.9 μM.
Acknowledgements
This study was supported by the National Natural Science Foundation of China (No. 21372189). The authors are grateful to Ms Wen-Yan Wang and Li Shen (School of Pharmaceutical Science, Yantai University) for the measurements of FAB-MS, HR-FAB-MS, UV, IR and NMR spectra. The authors also gratefully acknowledge Mr Hong-Bo Wang (School of Pharmaceutical Science, Yantai University) for the bioactivity screening.