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Abstract
This study was undertaken to evaluate antihyperlipidaemic and in vitro antioxidant activity of ethanolic extract of Flos populi (EFP). The results demonstrated that EFP contains 78.5% flavonoids and 10.4% phenolics, and it exhibited free radical-scavenging activity on 2,2-diphenyl-picrylhydrazyl (IC50 36.40 ± 0.62 μg/mL) and high reducing power (EC50 206.32 ± 1.6l μg/mL) under in vitro chemical assays. And irrespective of prophylactic administration or remedial administration, in high fat diet-induced hyperlipidaemic mice, oral treatment with EFP produced a decrease in the levels of serum total cholesterol, triglycerides, low-density lipoprotein-cholesterol and increase in high-density lipoprotein-cholesterol. In a word, in high fat diet-fed hyperlipidaemic mice, EFP (100, 200 and 400 mg/kg) significantly altered the plasma lipid levels to near normal. These results support a potential effect of EFP in cardiovascular disease.
Acknowledgements
This research work was supported by Nature Science Foundation of China (under Grant No. 31000154); National Science and Technology Support Program of China (under Grant No. 2011BAI03B01); National Nonprofit Industry Research Special Program of China (under Grant No. 201303111); Jilin Province Science and Technology Development Program (under Grant No. 20126046; 20140204013YY) and Special Program in the Pharmaceutical Industry in Jilin Province (under Grant No. YYZX201258).
Notes
1. These authors contributed equally to this work.