A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

Abstract

One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-α-l-rhamnopyranoside (1), together with one known α-dibenzopyrone, alternariol (2), and five xanthones (3–7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1–7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC₅₀ values of 12.2 μM.

Keywords::

• Arthrinium sp.
• sponge
• secondary metabolite
• naphthalene glycoside

Acknowledgements

This work was supported financially by the National Key Basic Research Program of China (973)’s Project (2010CB833800 and 2011CB915503), the Open-end Funds of Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology (2013HS005), the Open Foundation of the Key Lab of Marine Bioactive Substance and Modern Analytical Technique, SOA (MBSMAT-2013-02), the National Natural Science Foundation of China (Nos 31270402, 21172230, 20902094, 41176148 and 21002110), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264) and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002).