Compounds from marine-derived Verrucosispora sp. FIM06054 and their potential antitumour activities

Abstract

Strain FIM06054 was isolated from a marine sponge sample collected from the East China Sea and was characterised as a strain of Verrucosispora genus on the basis of its 16S rRNA gene sequence. One new compound, FW054-1 (1), together with a known aminofuran compound proximicin A (2), was isolated from the culture broth of Verrucosispora sp. FIM06054. Their structures were elucidated on the basis of spectral analysis. 1 and 2 showed antiproliferative activity against several human tumour cell lines.

Keywords::

• Verrucosispora
• proximicin A
• antitumour activity

Acknowledgements

We gratefully acknowledge financial support from the Fujian Key Project (2012Y0077) and the National Significant Science and Technology Major Project for novel medicinal research (2012ZX09301002-003). We thank Peng Fei and Xie Li-jun (Fujian Institute of Microbiology, Fuzhou, P.R. China) for helpful guidance on the identification of compounds.