A new glutarimide derivative from marine sponge-derived Streptomyces anulatus S71

Abstract

Four glutarimide-derived compounds including a new 3-[2-[2-hydroxy-3-methylphenyl-5-(hydroxymethyl)]-2-oxoethyl] glutarimide (1) and three known 3-[2-(2-hyroxy-3,5- dimethylphenyl)-2-oxoethyl] glutarimide (2, actiphenol), 3-hydroxy-3-[2-(2-hydroxy-3,5-dimethylphenyl)-2-oxoethyl] glutarimide (3) and 3-[2-[2-hydroxy-3-(hydroxymethyl)-5-methylphenyl]-2-oxoethyl] glutarimide (4), along with a known indole alkaloid 3-(hydroxyacetyl) indole (5), were isolated from ethyl acetate extract of the fermentation broth of the marine sponge-derived Streptomyces anulatus S71. Their structures were deduced by extensive studies of NMR and mass spectra.

Keywords::

• marine sponge
• actinomycete
• glutarimide
• Streptomyces anulatus S71
• polyketide synthase

Acknowledgements

We thank Mrs Xia Wei in Shanghai Institute of Organic Chemistry CAS for recording all NMR spectra. This work was financially supported by the 973 programmes (2010CB833805) from MOST, the key project (311018) and other grants from MOE.