Stimulating effect of a new triterpene derived from Anoectochilus elwesii on glucose uptake in insulin-resistant human HepG2 cells

Abstract

A new triterpene (1), 3-β-O-olean-11,13 (18)-diene-23,28-dioic acid, together with five known compounds (2–6), was isolated from Anoectochilus elwesii and their structures were elucidated by extensive spectroscopic methods and comparison with the literature data. Compound 1 was the first example of highly oxygenated triterpene obtained from Anoectochilus genus. The isolated compounds were evaluated on insulin-resistant human HepG2 cells for stimulating glucose uptake activity and the new compound displayed highly potent effect on the stimulation of glucose uptake in human HepG2 cells.

Keywords::

• Anoectochilus elwesii
• triterpene
• insulin-resistant human HepG2 cells

Acknowledgements

The authors thank Guangdong Natural Science Foundation (grant number S2013010014771) and National Natural Science Foundation of China (grant number 81001628) for financial support.

Conflict of interest

We declare that we have no conflict of interest.