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Natural Product Research
Formerly Natural Product Letters
Volume 29, 2015 - Issue 3
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Articles

Isolation and structural elucidation of novel antimicrobial compounds from maggots of Chrysomyis megacephala Fabricius

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Pages 239-246 | Received 22 May 2014, Accepted 22 Jul 2014, Published online: 21 Aug 2014
 

Abstract

The excretions/secretions from the maggot of Chrysomyis megacephala Fabricius are traditionally used to treat serious infections in China. In this study, bioassay-guided fractionation led to the isolation of three novel antibacterial compounds (13), including important fluorinated compounds (3 and 5), together with other nine known compounds from 70% methanol extract of C. megacephala. The structures of the new compounds were elucidated by NMR spectroscopic analysis and high-resolution mass spectroscopy. The antibacterial activities of the isolated compounds were evaluated using agar disc diffusion method. New compounds 1 and 2 exhibited moderate activity against Bacillus subtilis with a minimum inhibitory concentration (MIC) of 250 μg mL− 1. The most active compounds 3 and 5 displayed a broad spectrum of antimicrobial activity with an MIC of 125 μg mL− 1 against G+ and G−  bacteria. The structure of the above-mentioned novel compounds and their antimicrobial activities are herein reported for the first time from the natural product of insects.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [grant number 21242011].

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