A new lignan glycoside from the aerial parts and cytotoxic investigation of Uvaria rufa

Abstract

Chemical investigation of the aerial parts of Uvaria rufa (Dunal) Blume collected from Vietnam yielded one new lignan glycoside, ufaside (1), along with six known compounds, oxoanolobine (2), ergosta-4,6,8(14),22-tetraen-3-one (3), catechin (4), epicatechin (5), daucosterol (6) and glutin-5-en-3-one (7). Their chemical structures were determined by using NMR, HR-MS spectroscopic analyses and in comparison with the reported data. A cytotoxic analysis of U. rufa herb extracts was performed for the first time using nine human cancer cell lines (MCF-7, MDA-MB-231, LNCaP, MKN7, SW480, KB, LU-1, HepG2 and HL-60) derived from different tumour types. Of these seven constituents, compounds 2 and 3 displayed moderate cytotoxicity against the human lung adenocarcinoma cell line (LU-1) with IC₅₀ values of 9.22 ± 1.02 μg/mL and 10.21 ± 1.16 μg/mL, respectively.

Keywords::

• Uvaria rufa
• Annonaceae
• lignan glycoside
• ufaside
• cytotoxicity

Acknowledgements

This research was funded by the Hue University (Vietnam) under the grant number DHH2014-04-35. The authors are also grateful to the Institute of Chemistry, VAST for spectroscopic measurements.