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Abstract
Telekin is a eudesmane sesquiterpene-lactone naturally occurring in many medicinal plants with antitumour and anti-inflammatory activity. In this study, a series of 13-amino derivatives of telekin have been synthesised through Michael addition reaction, and their relative configurations were exemplified by the single crystal X-ray diffraction of the dimethylamine adduct. The in vitro cytotoxicity against three tumour cell lines of these amine derivatives was evaluated. The piperidine and 4-hydroxypiperidine adducts displayed stronger cytotoxic activity than telekin.
Additional information
Funding
This work was partly supported by the Basic Science Research Program of National Research Foundation from the Ministry of Education, Science and Technology of Korea [grant number 2014-002046]. Dr Xie also thanks for the support of the International Scholar Exchange Fellowship Program [grant number ISEF 2014-2015] from the Korea Foundation for Advanced Studies.
