Two new macrosporin dimers from the fungus Alternaria sp. XZSBG-1

Abstract

Two new macrosporin dimers (1–2) along with four known compounds (3–6) were isolated from the extracts of the fungal strain Alternaria sp. XZSBG-1 from the sediment of the salt lake in the Bange, Tibetan, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compounds 1 and 2 are new macrosporin dimers with symmetric chemical structures. In the cytotoxicity assay and inhibited alpha-glucosidase activity assay, all these compounds showed no notable inhibitory activity.

Keywords::

• macrosporin dimers
• Alternaria sp
• structure elucidation

Additional information

Funding

This work was supported by grant from China's Marine Commonwealth Research Project [grant number 201005022-2]; and supported by the National Natural Science Foundation of China [grant number 20772162], [grant number 21272286], [grant number 2126203]; and also supported by grant from The Key Project in Tibet Autonomous Region (2011).