A new triterpenoid bearing octacosanoate from the stems and roots of Clerodendrum philippinum var. simplex (Verbenaceae)

Abstract

A new triterpenoid bearing octacosanoate, named taraxer-3β-yl octacosanoate (1), together with 13 known compounds (2–14), was isolated from the ethanol extract of the stems and roots of Clerodendrum philippinum var. simplex. The structure of taraxer-3β-yl octacosanoate (1) was elucidated by extensive spectroscopic analysis. Uncinatone (8) and clerodenone A (10) exhibited inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC₅₀ values of 12.50 and 3.18 μM, respectively.

Keywords::

• Verbenaceae
• Clerodendrumphilippinum var. simplex
• taraxer-3β-yl octacosanoate
• anti-inflammatory activity
• Dai medicine

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Chinese Academy of Sciences (CAS) 135 programme [grant number XTBG-F02]; National Natural Science Foundation of China [grant number NSFC-U1302222].