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Natural Product Research
Formerly Natural Product Letters
Volume 30, 2016 - Issue 11
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Articles

New cytotoxic constituents from the Red Sea soft coral Nephthea sp.

Mohamed-Elamir F. HegazyPhytochemistry Department and Center of Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth st. (Former El Tahrir st.) Dokki, Giza, P.O. Box 12622, EgyptCorrespondence[email protected]
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,
Amira M. Gamal-EldeenCancer Biology Lab, Center of Excellence for Advanced Sciences, and Biochemistry Department, National Research Centre, 33 El Bohouth st. (Former El Tahrir st.) Dokki, Giza, P.O. Box 12622, EgyptView further author information
,
Tarik A. MohamedPhytochemistry Department and Center of Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth st. (Former El Tahrir st.) Dokki, Giza, P.O. Box 12622, EgyptView further author information
,
Montaser A. AlhammadyNational Institute of Oceanography and Fisheries, Red Sea Branch, Hurghada84511, EgyptView further author information
,
Abuzeid A. HassanienDepartment of Chemistry, Faculty of Science, Suez University, EgyptView further author information
,
Mohamed A. ShreadahNational Institute of Oceanography & Fisheries, Alexandria, EgyptView further author information
,
Ibrahim I. AbdelgawadDepartment of Chemistry, Faculty of Science, Suez University, EgyptView further author information
,
Eman M. ElkadyNational Institute of Oceanography & Fisheries, Alexandria, EgyptView further author information
&
Paul W. ParéDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX79409, USAView further author information
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Pages 1266-1272 | Received 20 Mar 2015, Accepted 20 May 2015, Published online: 13 Jul 2015
 
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Abstract

Nephthea are soft coral species rich in sesquiterpenoids and steroids. An organic extract of Nephthea sp. resulted in the isolation of a new steroid (1), as well as several previously reported metabolites (2–9). Structures were elucidated by employing NMR and HR-EI-MS analyses. The total extract, fractions and purified compounds exhibited differential cytotoxicity against the breast cancer MCF-7 cell line.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This project was supported financially by the Science and Technology Development Fund (STDF), Egypt [grant number 1102].

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Related Research Data

New cytotoxic constituents from the Red Sea soft coral Nephthea sp.
Source: Figshare
New cytotoxic constituents from the Red Sea soft coral Nephthea sp.
Source: Figshare
New cytotoxic constituents from the Red Sea soft coral Nephthea sp.
Source: Figshare

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