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Abstract
A furanone (1), (S)-methyl 2-(2-hydroxy-3,4-dimethyl-5-oxo-2,5-dihydrofuran-2-yl)acetate, was isolated from the edible mushroom Grifola frondosa. Mass spectrometry and NMR analyses were used to elucidate the structure of this compound, and its absolute configuration was determined using circular dichroism spectroscopy. Compound 1 exhibited specific antifungal activity against the plant pathogens, Fusarium oxysporum, Gibberella zeae and Piricularia oryzae and the opportunistic human pathogen, Pseudallescheria boydii, resulting in minimum inhibitory concentration values of 2.5, 2.5, 1.25 and 0.15 μg/mL, respectively. In contrast, the furanone showed only weak activity towards Aspergillus spp., Candida albicans and several other fungal strains tested as well as no appreciable antibacterial activity.
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This work was supported by the Chinese National Programs for High Technology Research and Development [grant number 2011AA10A203]; the Project of Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests [grant number Minjiaoke[2013]51]; the National Natural Science Foundation of China [grant number 31470156], [grant number 31170025], [grant number 31070026], [grant number 31201238]; the Fujian Agriculture and Forestry University Foundation for Distinguished Young Scholars [grant number xjq201406]; the Fujian Provincial Natural Science Foundation [grant number 2011J01068]; the China National Engineering Research Center of Juncao Technology [grant number JCJJ13013].
