One new 19-nor cucurbitane-type triterpenoid from the stems of Momordica charantia

Abstract

One new 19-nor cucurbitane-type triterpenoid (3β,9β,25-trihydroxy-7β-methoxy-19-nor-cucurbita-5,23(E)-diene) (1), together with other six known cucurbitane-type triterpenoids (2–7), were isolated from the stems of Momordica charantia L. The chemical structure of 1 was elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY and ROESY), MS experiments. Using MTT assay, compound 1 exhibited weak cytotoxicity against HL-60, A-549, and SK-BR-3 cell lines with the IC₅₀ values at 27.3, 32.7 and 26.6 μM, respectively.

Keywords:

• Momordica charantia L
• 19-nor cucurbitane-type triterpenoid
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was financially supported by Industry, Education and Academy Program of Henan Province [grant number 142107000029].